Edwin Chapman is interested in the molecular mechanisms underlying neuronal membrane fusion, synaptic transmission, and synaptic plasticity. Chapman and his team are focused on elucidating the mechanisms that mediate calcium-triggered exocytosis in neurons and neuroendocrine cells, as well as a number of related membrane trafficking and synaptic function questions. They use a range of techniques in their work, including multiple single-molecule approaches, steady-state and time-resolved fluorescence spectroscopy, and live-cell imaging and electrophysiology.