Current Research
Mechanisms and Regulation of Tissue Growth and Homeostasis

Duojia Pan investigates the genetic and molecular mechanisms that control organ size in animals. Working in Drosophila and mice, Pan and his team are working to pinpoint size-control genes, place them in signaling networks, and study how these networks regulate tissue development and homeostasis. They showed that the Hippo signaling pathway plays a critical role in halting organ growth in both flies and mammals, and that dysregulation of the pathway leads to tumor growth in mammals. Now, the team is focused on further elucidation of the mechanisms, regulation, and evolution of Hippo signaling, as well as the discovery of new growth control pathways.

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