David Walt pioneered the use of microwell arrays for single-molecule detection and analysis. Walt’s research applies his ultrasensitive single-molecule array technology to pressing diagnostics problems, including cancer, infectious disease, and neurological disorders. He and his lab members are investigating single-molecule enzymology to provide insight into enzyme mechanisms. Walt brings inquiry-based genomics and bioinformatics experiments to high school and college students. These experiments engage students through peer mentors using hands-on genetics protocols followed by data processing and analysis.