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David Bartel investigates the molecular pathways that regulate gene expression by affecting the stability or translation of mRNAs. Bartel and his team study microRNAs and other small RNAs that specify the destruction or translational repression of mRNAs. In addition, they study how mRNA introns, untranslated regions, and poly(A) tails recruit and mediate regulatory phenomena. As part of their work, the team develops new tools for high-throughput molecular measurements, which help to inform their computational analyses and in-depth mechanistic studies.