Current Research
Mechanisms That Regulate Growth and Metabolism

David Sabatini studies the molecular pathways that regulate growth and metabolism in mammals, and how they are deregulated in diseases like cancer and diabetes. Sabatini and his team focus their efforts in part on the mTOR pathway, a critical regulator of growth signals that is under the control of nutrients, stress, and growth factors like insulin. They also study the metabolic processes that are necessary for cancer cells to proliferate and survive in tumors. In addition, the team develops technologies, such as cell-based microarrays and large-scale genetic screens, that they use in their work and share with the larger community.

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