Over a 50-year career, former HHMI scientist and leader David Clapham reshaped our understanding of ion channels by relentlessly pursuing experimental evidence across scientific disciplines. HHMI Investigator Leslie B. Vosshall, PhD, will become Vice President and Chief Scientific Officer, effective February 1, 2022. An ion channel called TRPC5 acts as a molecular cold sensor in teeth and could serve as a new drug target for treating toothaches.