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David Page is interested in the differences and similarities between males and females, in both healthy and disease states. Page and his team are investigating the contributions of the X and Y chromosomes to sex differences at the genomic, epigenetic, molecular, and cellular levels. They are exploring molecular-level variations in organs and systems where diseases with sex-based differences manifest, such as the immune system, heart, and brain. They also study individuals with a wide range of sex chromosome complements to understand the influence of the X and Y chromosomes on gene regulation across the entire genome.