Current Research
Design of New Functional Proteins

David Baker wants to understand the fundamental principles underlying protein structure and function, and to apply those principles to create computer-designed proteins to address challenges in health and technology. Baker and his team do not re-engineer native proteins; instead, they iterate between computation and experiment, working to continually improve their design methodology. Current projects include, among others, designing molecular switches, enzymes, and motors; designing delivery vehicles for targeted intracellular delivery of biologics; and developing methods to design high-affinity binders to small molecule and protein targets.

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