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Darrell Irvine works to engineer immunity through a fusion of immunology with biotechnology and materials chemistry. Irvine and his team employ a biotechnology- and materials science-based approach to create new therapies for controlled modulation of the immune system, with an eye toward preventing and treating human disease. Their projects fall into three complementary themes: smart materials and nanotechnology for enhanced vaccines; nanomaterials-enabled immunotherapy to enhance anti-tumor immune responses; and new tools to monitor and manipulate immune cells and increase fundamental understanding of the immune system.