Daniel Mucida studies the relationship between gut microbes, diet, and immunity. Mucida and his team investigate the mechanisms and processes involved in intestinal homeostasis and the consequences when such processes are compromised. Their research seeks to reveal how the intestine generates protective responses against invading pathogens (resistance) while absorbing microbe- and food-derived beneficial molecules (tolerance). The team has identified gut-specific environmental cues, cellular circuits, and molecular pathways critical to resistance and tolerance. In addition, they are defining mechanisms by which luminal stimulation influences systemic immunity, demonstrating the importance of gut-epithelium imprinting on lymphocytes for homeostasis, and describing neuro-immune interactions that modulate intestinal physiology and response to microbes.