Current Research
Dynamic and Reversible RNA and DNA Methylation

Chuan He wants to understand the dynamic modifications of RNA and DNA, and their roles in gene expression regulation. Using chemical and biological tools, some of which they develop, He and his team study the scope and mechanisms underlying RNA modifications, as well as their broad impacts on mammalian development and human diseases. They develop genomics tools to facilitate studies of basic biology and human diseases. The team is evaluating DNA modifications as potential biomarkers for disease diagnosis and prognosis.

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