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Christopher Walsh is interested in the fundamental mechanisms directing human brain development. Walsh and his team focus on human genetic and basic molecular biology research, working to identify genes associated with brain disorders affecting children – such as microcephaly, autism, and epilepsy – and to study the mechanisms of these genes. The team’s work may lead to better options for diagnosis, management, and treatment for affected individuals and their families. Other research by the team has characterized the neuronal genome at the single-cell level and found that every neuron has distinctive patterns of mutation reflecting its developmental origin and the effects of aging.