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Charles Zuker is interested in the mechanisms underlying signal processing and information transfer in sensory systems. Zuker and his team use the mammalian taste system to understand how the outside world is represented in the brain to guide actions and behaviors. Taste behaviors are exquisitely modulated by the internal state (e.g., hunger, satiety, emotion, and expectation), thus they provide a powerful model for the dissection of brain circuits integrating the senses with our physiological and emotional states.