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Charles Sawyers is interested in the signaling pathways that drive cancer cell growth. Sawyers and his team study the molecular details underlying tumor growth and progression, with an eye toward designing new treatment options for patients with chronic myeloid leukemia, prostate cancer, and glioblastoma. Currently, the team is investigating molecular strategies to quell the ability of prostate cancer to develop resistance to anti-androgen hormone therapy. They are also exploring how specific prostate cancer associated mutations affect cellular function, using genetically engineered mouse models and prostate tissue cultures.