Across the planet, behavior and physiology are coordinated into daily rhythms that align our lives to the rotation of the Earth. These circadian rhythms are generated at the cellular level, where they promote health and well-being by integrating cellular function across an organism. Carrie Partch’s lab strives to understand the molecular basis of circadian timekeeping by studying the structure, dynamics, and interactions of dedicated clock proteins. The conservation of some protein folds in clocks, like the PAS domain, offers a chance to harness their small molecule binding properties to control clocks with drugs. Partch’s lab aims to build on a molecular understanding of biological clocks to improve human health and well-being on Earth and beyond.