Biochemistry, Molecular Biology
Janelia Research Campus
Dr. Wu is a senior fellow at the Janelia Research Campus.
Chromatin Structure and Function
Carl Wu is a senior fellow at Janelia. Wu studies the molecular architecture of chromosomes and the role of chromatin structure in gene transcriptionareas that are central to understanding how genomic information is programmed for selective expression in the development of the organism. Wu received his BS from St. Mary's College and his PhD in biology from Harvard University, where he began his study of chromatin organization under Sarah Elgin. While a Junior Fellow at Harvard under Wally Gilbert, Wu found that the chromatin of gene promoters is remodeled as DNase I hypersensitive sites. From Harvard, Wu moved to the National Cancer Institute where he investigated biochemical mechanisms of chromatin remodeling for three decades and served as Chief of the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research. At Janelia, Wu is extending his work in new directions, developing fresh analytical methods for the epigenome and imaging local chromatin dynamics and large-scale chromatin folding in live cells.