In a collection of 11 newly published research papers, genomics further proves its worth by identifying species at risk for extinction, predicting the appearance and performance of a legendary sled dog, and illuminating once-dark corners of evolution and biology.  A bold project to read the complete genetic sequences of every known vertebrate species reaches its first milestone by publishing new methods and the first 25 high-quality genomes. The first complete genetic sequences of individual mountain lions point the way to better conservation strategies for saving threatened populations of the wild animals.