Aviv Regev wants to understand the function of complex molecular circuits in cells and tissues and predict their response to genetic and environmental changes, cellular differentiation, evolution, and disease. Regev and her team develop experimental and computational approaches to infer cellular and tissue circuits by combining perturbation, profiling, and computational inference. They extensively apply these approaches in primary mammalian cells, especially those from the immune system, and in mammalian tissues, especially epithelia, such as from the gut and lung. Regev’s team has been a leading pioneer of single-cell genomics experimental and computational methods. Regev is also a founding co-chair of the Human Cell Atlas initiative.