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Arul Chinnaiyan seeks to understand the biological origins of solid tumors, to better understand cancer biology as well as to discover clinical biomarkers. Using approaches from genomics, proteomics, and bioinformatics, Chinnaiyan and his team study biopsied patient specimens to identify altered genes that drive the formation of solid tumors. In addition to his team’s seminal work on gene fusions in prostate cancer, Chinnaiyan has also led the development of a cancer profile bioinformatics resource and has been involved in developing high-throughput clinical sequencing approaches for precision oncology. His work has implications for improved disease diagnosis, prognosis, and therapy.