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Anoj Ilanges studies the role of the nervous system in coordinating changes in behavior, autonomic function, and metabolism during shifts in physiological states. Our bodies maintain our physiology within a narrow range, but they can also drastically change our physiology in response to both external and internal stimuli. These physiological state changes can be transient (for minutes or hours) or can last for much longer (on the order of days or weeks). Ilanges and his team use a combination of molecular profiling, cellular imaging, functional manipulations, and organism-level phenotyping in mice and zebrafish to interrogate the mechanisms driving dramatic, adaptive states such as the sickness state during our body’s response to infection.