Current Research
RNA Biology: Tertiary Structure and RNA-Protein Machines

Anna Marie Pyle wants to understand the molecular interactions that are important for the assembly of RNA structures and the activities of RNA-protein machines. Using tools ranging from crystallography to enzymology to cell culture, Pyle and her team investigate the impact of RNA architecture and dynamics on cellular function. In parallel, they develop new computational methods for solving and analyzing RNA structures. Their work has the potential to inform new strategies for the detection and treatment of viral and fungal pathogens such as hepatitis C, dengue, and Candida.

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