Angela Phillips is uncovering the molecular determinants of host-virus evolution. She focuses on the mutations that fuel the evolutionary arms race between viral proteins and antibodies, investigating how they enable viruses to escape antibodies, and antibodies to recognize new viruses, without compromising the stability or function of these proteins. Her lab tackles these questions by developing high-throughput methods to measure stability and function for millions of proteins in parallel. They then integrate this rich information to develop predictive evolutionary models, which they hope will be useful for forecasting the emergence of new viral variants and designing long-lasting vaccination strategies.