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Andre Dillin is interested in why an aging organism begins to lose control over the integrity of its proteome, and how this loss is communicated across its various tissues. Working in model systems ranging from stem cells to nematodes to mice, his team has developed and applied techniques that allow manipulation of signaling pathways or proteins within a tissue, a single cell, or a single organelle, so they can observe the effect of that small perturbation on the physiology of a whole organism. Dillin’s work aims to shed light on the developmental processes of human neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases.