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Allan Spradling is interested in the biology of reproduction, particularly oogenesis – the process of egg formation. Working in Drosophila and mice, Spradling and his team focus on multiple aspects of oogenesis, including germline cyst formation, oocyte and nurse cell specification, the germline chromatin cycle, oocyte storage in vivo, and environmental and nutritional influences.  There work has been informed by areas of evolutionary conservation between Drosophila and mammalian oogenesis. In addition, the team is interested in developing better tools and resources for these studies to share with the scientific community.