Alison Tebo is interested in using protein engineering to develop chemical biology tools that can sense and manipulate biological processes. In particular, Tebo and her team focus on tools that can be used to decipher the interactions of different types of cells – their signaling and metabolite exchange processes, migration patterns, and interplay with other cell types, intruders, and their environment. To that end, they are currently exploring projects related to affinity reagents, manipulation of enzyme activity, and manipulation and detection of cell-cell and cell-matrix interactions.