In a study that followed hundreds of mice over their lifespans, calorie restriction combined with time-restricted eating boosted longevity. The parasite that causes malaria has its own internal clock, explaining the disease’s rhythmic fevers and opening new pathways for therapeutics. The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep. Six HHMI scientists have been elected to membership in the Institute of Medicine. Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled. HHMI scientists have determined the three-dimensional structure of two proteins that help keep the body’s clocks in sync.