Anna Marie Pyle wants to understand the molecular interactions that are important for the assembly of RNA structures and the activities of RNA-protein machines. Using tools ranging from crystallography to enzymology to cell culture, Pyle and her team investigate the impact of RNA architecture and dynamics on cellular function. In parallel, they develop new computational methods for solving and analyzing RNA structures. Their work has the potential to inform new strategies for the detection and treatment of viral and fungal pathogens such as hepatitis C, dengue, and Candida.
Humans and many other organisms depend on molecular systems that cut and reconnect their genetic material. A new study explores the workings of an ancient splicing mechanism still present in bacterial cells. Thirteen project teams involving 70 scientists from 29 institutions are collaborating on basic research targeted at preparedness for future emerging pathogens that could threaten human health. The novel coronavirus uses structures within its RNA to infect cells. Scientists have now identified these configurations, generating the most comprehensive atlas to date of SARS-CoV-2’s genome.