Lucas Farnung investigates the molecular mechanisms governing chromatin structure and function during transcription and DNA replication. Farnung and his lab integrate biochemical and biophysical methods with structural biology techniques, including cryo-electron microscopy and protein structure prediction, to elucidate how transcription and replication machineries interact with nucleosomes, histone modifiers, and chromatin remodelers. This work aims to uncover fundamental principles of gene expression and epigenetic inheritance. By exploring how chromatin architecture modulates the flow of genetic information, Farnung’s research provides insights into the regulatory mechanisms that cells use to reliably interpret their genetic instructions.