Corina Amor Vegas studies aging, with the ultimate goal of improving human healthspan. Specifically, her laboratory is focused on the biology of senescent cells. Senescence is a stress-response program that is triggered in damaged cells and leads to their elimination by the immune system. As we age, however, our body accumulates senescent cells that our immune system is no longer able to effectively eliminate. This accumulation generates a chronic pro-inflammatory microenvironment that leads to age-related diseases like fibrosis, dementia, or cancer. Amor Vegas and her group seek to understand how the immune system targets these cells in physiological conditions. Further, the group aims to leverage their findings to develop immune-based therapeutic approaches, such as “senolytic” CAR T-cells, to target senescent cells in aging.