Over the last decade, the rhomboid superfamily of proteins has been uncovered as regulators of diverse membrane-related processes, and yet almost nothing is known about the molecular mechanism by which they carry out their functions. Sonya Neal strives to understand the widely conserved rhomboid proteins by leveraging yeast, human cells, and zebrafish for complete characterization of rhomboid proteins at the mechanistic, cellular, and organismal level. Ultimately, her research holds great promise in revealing new fundamental mechanisms, which will be harnessed to tackle rhomboid-related diseases.