The “resolution revolution” in structural biology has yielded unprecedented insights into the molecular mechanisms that enable protein function. Yet, these insights fall short of delivering a full understanding, as they lack the crucial context of the cellular environment. José Velilla is leveraging advances in the fields of electron microscopy and mass spectrometry to bridge the atomic and cellular scales in understanding G protein-coupled receptor signaling from unconventional cell locations. G protein-coupled receptors are critical to a variety of physiological processes, including sight, taste, blood pressure regulation, and glucose metabolism.