Nels Elde investigates interactions between pathogenic microbes and their hosts. Specifically, Elde and his team compare host-microbe interfaces to understand how evolution acts to diversify immune systems and fundamental cellular processes. Combining evolutionary analysis and experimental approaches, the team pinpoints mutations and studies the impact of genetic variation. Their research is revealing new classes of antiviral genes and unexpected differences in core cellular and physiological processes. The team is also uncovering means by which viruses adapt to host defenses and the impacts of selfish genetic elements on the origins and regulation of immune functions. This work points to a central role for microbes in shaping cell biology.
Many tend to think of evolution as an event that occurred too long ago to comprehend. But, HHMI Investigator Nels Elde and his lab study how hosts evolve resistance to pathogens – sometimes over vastly different stretches of time. The group’s insights also shed light on how pathogens adapt, including viruses that impact human health. HHMI is known for our “people, not projects” philosophy. In this newly launched video series, we’re shining the spotlight on several of our scientists to share their stories and offer a behind-the-scenes glimpse at what makes their work – and their labs – unique.