Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Eric Betzig, director de grupo en Janelia, gana el Premio Nobel por el desarrollo de la microscopía de fluorescencia de super-resolución.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.
HHMI researchers show that rising temperatures can cause spread of malaria to areas where the disease had not been endemic historically.
Investigadores del HHMI demuestran que el aumento de temperaturas puede causar la dispersión de la malaria en zonas donde la enfermedad no ha sido endémica históricamente.
Howard Hughes Medical Institute (HHMI) scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.
New research from HHMI scientists reveals how a foreign-DNA-destroying system, known as CRISPR, efficiently locates its DNA targets within a bacterial genome.
By studying which genes modern humans still retain from our Neanderthal ancestors, researchers are able to tell a clearer story about the biological impact of human-Neanderthal interbreeding.
HHMI seeks to appoint up to 25 new biomedical researchers through a national open competition.
HHMI researchers identify a potential Achilles heel in the oncogene K-Ras.
A new technique developed by Janelia researchers allows scientists to use electron beams to determine protein structure from tiny crystals.
New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer.
HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient’s body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs.
HHMI researchers have developed a mouse model of scleroderma. Their studies have uncovered some of the molecular pathways that go awry to cause the disease.
Neurons deep in the fly’s brain tune in to some of the same basic visual features that neurons in bigger animals such as humans pick out in their surroundings. The new research is an important milestone toward understanding how the fly brain extracts relevant information about a visual scene to guide behavior.
HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
La Real Academia de las Ciencias Sueca anunció que los investigadores del HHMI, Randy W. Schekman y Thomas C. Südhof, y James E. Rothman de la Universidad de Yale son los ganadores del Premio Nobel de Fisiología o Medicina 2013 por sus descubrimientos sobre la maquinaria que regula el tráfico de vesículas, un importante sistema de transporte de nuestras células.
The Nobel Assembly at the Karolinska Institute announced that HHMI investigators Randy W. Schekman and Thomas C. Südhof, and Yale's James E. Rothman are the recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Janelia scientists launch collaboration to develop a new generation of devices to detect neural activity.
Some breast cancer cells have a leg up on survival—the genes they express make them more likely to spread and prosper in bone tissue.
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells.
New thinking and technological innovation help Janelia researchers piece together a complex map of the neuronal connections that flies use to detect motion.
By activating a subset of brain cells in mice, researchers changed the way the animals remembered a particular setting.
New research reveals the cellular network that activates temperature-sensitive changes in an infectious fungus.
A new protein engineered by scientists at the Janelia Farm Research Campus fluoresces brightly each time it senses calcium, giving the scientists a way to visualize neuronal activity. The new protein is the most sensitive calcium sensor ever developed and the first to allow the detection of every neural impulse.
New research reveals details of changing DNA methylation patterns as the brain matures.
Proteins engineered to bind enhancer regions of the genome offer researchers a window into how genes are activated.
Scientists have identified a gene that enables wheat crops to fight off stem rust, a dreaded fungus that blights wheat fields with rusty brown lesions and reduces yields.
When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder.
In one of the first successful attempts at genetically engineering mosquitoes, researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET.
Malaria parasites infecting human red blood cells send packets of information between cells to coordinate group activity. When the parasites are under stress, the communication increases their ability to develop into a new stage of the life cycle.
New research shows that about 10 percent of severe cases of congenital heart disease are caused by genetic mutations that are absent in the parents of affected children.
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Waging an immunological war against a pathogen is not the body’s only way to survive an infection. Sometimes learning to live with an invader can be just as important.
Scientists have discovered a hormone that causes the body’s insulin-producing factories, beta cells, to churn out more of themselves.
A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
A new DNA sequencing technique has enabled researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium.
eLife makes first collection of research articles available online.
Robert Lefkowitz de HHMI comparte el premio con Brian Kobilka por estudios sobre los receptores acoplados a proteínas G.
Only a few animals, such as songbirds, whales, and dolphins, are known to be vocal learners, modifying the sequence or pitch of their sounds based on what they hear from other members of their species. New evidence suggests mice can be added to that list.
HHMI's Robert Lefkowitz shares prize with Brian Kobilka for research on G-protein coupled receptors.
HHMI and the University of KwaZulu-Natal open new research institute in Durban, South Africa.
In experiments with rats, researchers found that the rejection of an old belief correlates with abrupt changes in activity in a region of the brain involved in cognitive functions such as reward anticipation and decision-making.
HHMI selects 13 of the world’s leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences.
HHMI investigator Ronald D. Vale of UCSF will share the 2012 Albert Lasker Basic Medical Research Award.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
A discovery of how ethylene triggers changes in gene activity could lead to new ways to stop or slow ripening.
The vaccinia virus increases the size of its genome when it confronts the immune system, thereby increasing the odds of a random mutation that will improve its survival.
By investigating the cause of a fatal snake disease, scientists have found a virus that links two known virus families that can cause fatal hemorrhagic fevers in humans.
Mutations in four different DNA damage repair genes have been linked to chronic kidney disease.