HHMI researchers track down the genes responsible for establishing the characteristic swirl of a snail shells.
A new microscopy technique that uses the principles underlying holography is helping researchers speed up imaging and optically manipulate living cells.
HHMI will award up to $25 million for a unique program that prepares scientists to translate laboratory discoveries into new medical treatments.
New ways of imaging sugar molecules are creating a vibrant new biological frontier.
A 20 year search has helped international research scholar Hugo D. Luján explain how the Giardia parasite hides from the immune system.
Al igual que una pandilla de bandidos que se cambia la ropa después de un robo para evitar ser capturados, el parásito intestinal Giardia lamblia altera su aspecto para engañar al sistema inmune humano. Después de una búsqueda de 20 años, experimentos realizados por el Becario Internacional de Investigación del Instituto Médico Howard Hughes, Hugo D. Luján, revelan cómo cambia sus disfraces el parásito.
Starved cone cells in the eye may nibble themselves to death in people with retinitis pigmentosa.
Una de las razones por las que mueren las células responsables de la visión de los colores en personas con retinitis pigmentosa puede ser que las células se comen a sí mismas cuando son privadas de nutrientes.
At least one of every four melanoma cells has the capacity to seed the development of new tumors.
By manipulating a newly identified regulatory protein, researchers can reactivate a dormant fetal hemoglobin gene--possibly with therapeutic benefits for patients with life-threatening anemias.
Scientists have created a new mouse model that may help explain how a rare disease causes otherwise supple soft tissue and joints to turn into bone.
HHMI researchers have uncovered a molecular explanation for the profound fatigue brought on by mild exercise in some people with muscular dystrophy.
Researchers have identified a molecule that tells your brain when it's time to say no to a second piece of pie and push back from the Thanksgiving table.
Investigadores identifican una molécula que le dice al cerebro que ha llegado el momento de decirle no a un segundo pedazo pastel de calabaza y alejarse de la mesa del Día de Acción de Gracias.
Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.