HHMI’s Science Education Alliance is transforming the undergraduate introductory science experience at more than 150 two- and four-year institutions across the US. These same students are making discoveries that could change how scientists tackle bacterial infections and antibiotic resistance. While white fat stores calories, brown fat burns them. A new study reveals that brown fat improves metabolic health by providing nutrients important to other organs, rather than warming up body temperature. New research shows that a region of the brain can ramp the immune system both up and down, opening the door to new scientific discoveries—and to new approaches to tackling a wide range of immune system disorders and diseases, from rheumatoid arthritis to toxic shock syndrome.Loren Frank’s HHMI lab at UCSF has pioneered an ambitious framework for sharing vast neuroscience datasets and complicated analysis methods, a step towards tipping the culture of science towards more effective and fruitful collaboration. Precision genome editing tools – including prime editing – enable scientists to model genetic variants in their native environment. Now, researchers have developed a framework for engineering and measuring the effects of thousands of genetic mutations simultaneously while accurately quantifying the efficiency of prime editing. They’ve even found that some mutations once considered to be inconsequential or nonpathogenic may contribute to cancers. HHMI Professor Marla Geha launched a first-of-its-kind program at Yale that provides military veterans hands-on research experience in their undergraduate years. The program will welcome a new cohort this summer.The program recognizes early career faculty who are committed to advancing inclusivity in science. Each Scholar is appointed for up to two five-year terms, receiving up to $8.6 million in total support over 10 years.HHMI Investigator Sangeeta Bhatia’s lab developed a low-cost, point-of-care platform to detect lung cancer via a simple urine test. Penniman brings more than 25 years of leadership in nonprofit and human health communications.The program provides up to $1.5 million in support for early career scientists who have the potential to become inclusive leaders in academic research.