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Showing 1-37 of 37 Resources
  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • Using p53 to Fight Cancer

    Using p53 to Fight Cancer

    Animation

    (1 min 2 sec) This animation demonstrates how cancerous cells could be destroyed using a modified virus.

  • Cancer and Cell Fate in the Intestinal Epithelium

    Cancer and Cell Fate in the Intestinal Epithelium

    Animation

    (2 min 17 sec) Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer. Also available in Spanish.

  • Angiogenesis

    Angiogenesis

    Animation

    (1 min 12 sec) A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs. Also available in Spanish.

  • VEGF

    VEGF

    Animation

    This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

  • p53

    p53

    Animation

    (26 sec) A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

  • The p53 Gene and Cancer

    The p53 Gene and Cancer

    Click & Learn

    This Click and Learn explains the structure and function of the p53 protein as well as how the protein’s activity is regulated.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Genetic Mutations and Disease

    Genetic Mutations and Disease

    Poster

    The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Cell Division and Cancer Risk

    Cell Division and Cancer Risk

    Data Point

    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • Sequencing HHMI BioInteractive Cancer Resources

    Why don’t we have a cure for cancer? This question arises from a series of misconceptions: that cancer is one disease, caused by one gene that is the same in all people. To address these...

  • Meet Charles Sawyers

    Meet Charles Sawyers

    Clip

    (2 min 27 sec) Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer. 

  • Damage to DNA leads to mutation

    Damage to DNA leads to mutation

    Animation

    (1 min 7 sec) Reactive molecules, such as free radicals, and solar ultraviolet radiation can lead to mutations in DNA. Most mutations are corrected, but in rare cases mutations can accumulate and cause diseases such as cancer.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Point

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • Learning from Patients: The Science of Medicine

    Learning from Patients: The Science of Medicine

    Lecture

    As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

  • Structure and Function of Telomeres

    Structure and Function of Telomeres

    Click & Learn

    This mini-lesson covers the research on telomeres that has happened since the 1995 Holiday Lectures.

  • Genetic Mutations and Disease Interactive

    Genetic Mutations and Disease Interactive

    Click & Learn

    This interactive focuses on the roles of germline and somatic cell mutations in human disease. It supports the 2013 Holiday Lectures on Science, Medicine in the Genomic Era.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Lecture

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Mismatch Repair

    Mismatch Repair

    Animation

    (1 min 22 sec) This animation illustrates how mistakes made during DNA replication are repaired.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Video

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • Using the Identify and Interpret Strategy with Data Points

    I find that getting students excited about biology and engaging them in the practices of science can be challenging with certain topics. For example, with mitosis and the cell cycle, students...

  • Resources from Past Workshops

    Click on the workshop title to view a PDF containing links to the resources presented. NSTA STEM Forum & Expo | Minneapolis, MN | May 20–22, 2015 Mutations, the Cell Cycle, and Cancer Megan...

  • Click and Learn App

    Click and Learn App

    Apps and eBooks

    Interactively explore topics in biology with the Click and Learn app. Now available from the Apple App Store, Google Play, and Amazon Apps!

  • Using BioInteractive Resources with English Learners

    Although I have no formal training as an English Learner teacher, I have, like many teachers in similar situations, taught dozens of EL students over the years. I have had plenty of formal training...

  • BioInteractive at NSTA in Chicago

    BioInteractive will be in Chicago March 12–14 for the National Science Teachers Association National Conference. Stop by booth #1532 to pick up resources and join us at our hands-on workshops...

  • The BioInteractive Team

    The BioInteractive Team

    HHMI’s BioInteractive website provides a wide array of free science education resources for the classroom. They are produced by a core team of scientist educators, graphic artists, video producers, and outreach professionals working in close collaboration with science teachers and undergraduate educators, scientists, film producers, animators, and programmers #mini-panel-biointeractive_summary h2 { display: none; }

  • Subscribe to Our E-Newsletter

      BioInteractive’s FREE resources are targeted to high school and undergraduate audiences. They are developed, vetted, and field-tested by educators and...

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