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  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Models

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Models

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • Using p53 to Fight Cancer

    Using p53 to Fight Cancer

    Animations

    (1 min 2 sec) This animation demonstrates how cancerous cells could be destroyed using a modified virus.

  • Cancer and Cell Fate in the Intestinal Epithelium

    Cancer and Cell Fate in the Intestinal Epithelium

    Animations

    (2 min 17 sec) Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer. Also available in Spanish.

  • Angiogenesis

    Angiogenesis

    Animations

    (1 min 12 sec) A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs. Also available in Spanish.

  • VEGF

    VEGF

    Animations

    This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

  • p53

    p53

    Animations

    (26 sec) A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

  • The p53 Gene and Cancer

    The p53 Gene and Cancer

    Click & Learn

    This Click and Learn explains the structure and function of the p53 protein as well as how the protein’s activity is regulated.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animations

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Genetic Mutations and Disease

    Genetic Mutations and Disease

    Posters

    The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animations

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Science Talks

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Cell Division and Cancer Risk

    Cell Division and Cancer Risk

    Data Points

    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

  • Cancer Cell Invasion

    Cancer Cell Invasion

    Phenomenal Images

    Students explore a photo of tissues and cells as an anchoring phenomenon to explore the invasion of cancer cells into muscle tissue.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Science Talks

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Science Talks

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clips

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activities

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

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