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Showing 1-55 of 55 Resources
  • Sodium Channel Evolution in Electric Fish

    Sodium Channel Evolution in Electric Fish

    Data Points

    Scientists investigated how gene duplication contributed to the evolution of electric fish.

  • Sex Verification Testing of Athletes

    Sex Verification Testing of Athletes

    Click & Learn

    This interactive explores the biology of sex determination and development in humans, set against the backdrop of the different sex testing policies implemented throughout sports history.

  • Monkey Social Status and Immune Response

    Monkey Social Status and Immune Response

    Data Points

    Scientists studied how the dominance ranking of female rhesus macaques living in social groups affected the expression of genes linked to immune response.

  • Resource Guides

    Resource Guides

    Collection

    Designed by educators, BioInteractive’s resource guides will help you select BioInteractive resources aligned to specific topics and standards, including the AP® Biology Curriculum Framework.

  • Think Like a Scientist: Natural Selection in an Outbreak

    Think Like a Scientist: Natural Selection in an Outbreak

    Scientists at Work

    (7 min 29 sec) This video focuses on the front lines of the 2013–2016 Ebola outbreak in West Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

  • Genetic Mutations and Disease Interactive

    Genetic Mutations and Disease Interactive

    Click & Learn

    This interactive focuses on the roles of germline and somatic cell mutations in human disease. It supports the 2013 Holiday Lectures on Science, Medicine in the Genomic Era.

  • Understanding Variation in Human Skin Color

    Understanding Variation in Human Skin Color

    Lessons

    In this activity, students extend the concepts covered in the short film The Biology of Skin Color through the application of models and mathematical thinking to explain how genomic variation and human ancestry can explain differences in skin color, a polygenic trait.

  • Zebrafish and Skin Color

    Zebrafish and Skin Color

    Lessons

    This lesson complements the film The Biology of Skin Color and explores how experimental work in zebrafish led to a better understanding of the role of the gene SLC24A5 in human skin color.

  • Alzheimer’s Disease: Piecing Together the Evidence

    Alzheimer’s Disease: Piecing Together the Evidence

    Click & Learn

    This interactive explores evidence from brain anatomy, tissue histology, and genetic studies to reveal possible targets for the treatment of Alzheimer’s disease.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Points

    This activity analyzes a published scientific figure from a study of a family that has a high prevalence of Alzheimer’s disease.

  • Lactase Film with Quiz

    Lactase Film with Quiz

    Interactive Videos

    (14 min 52 sec) Embedded quiz modules test students’ understanding as they watch a short film that explores the evolution of the ability to digest lactose as adults (lactose tolerance) and the genetic changes associated with the trait.

  • Skin Color Film with Quiz

    Skin Color Film with Quiz

    Interactive Videos

    (18 min 58 sec) Embedded quiz modules test students’ understanding as they watch a short film that explores the evidence for the evolution of the variation in skin color among human populations.

  • Genetic Origin of Variation in Human Skin Color

    Genetic Origin of Variation in Human Skin Color

    Data Points

    Dr. Rebecca Lamason and colleagues studied the genetic origin of variation in human skin color using a model organism, the zebrafish.

  • Activity for The Biology of Skin Color

    Activity for The Biology of Skin Color

    Film Activities

    This activity explores the evidence that differences in human skin color are adaptations to varying intensity of UV light, as discussed in the short film The Biology of Skin Color.

  • How We Get Our Skin Color

    How We Get Our Skin Color

    Animations

    (3 min 32 sec) This engaging animation shows how human skin cells produce the pigment melanin, which gives skin its color. 

  • The Biology of Skin Color

    The Biology of Skin Color

    Short Films

    (18 min 58 sec) This film explores the hypothesis that different tones of skin color in humans arose as adaptations to the intensity of ultraviolet radiation in different parts of the world.

  • Icefish Film with Quiz

    Icefish Film with Quiz

    Interactive Videos

    (13 min 14 sec) Embedded quiz modules test students’ understanding as they watch the short film on the icefish—an example of how genes are reused and recycled.

  • Pedigrees and the Inheritance of Lactose Intolerance

    Pedigrees and the Inheritance of Lactose Intolerance

    Lessons

    In this activity, students explore concepts covered in the short film Got Lactase? The Co-evolution of Genes and Culture about the genetic variations associated with lactose tolerance/intolerance and how the trait is inherited in families.

  • Holiday Lecture 2004 Update—Jeff Friedman

    Holiday Lecture 2004 Update—Jeff Friedman

    Clips

    (3 min 52 sec) HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

  • Dante's Story

    Dante's Story

    Clips

    (6 min 6 sec) Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clips

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Meet Dante—A Young Boy with Hemimegalencephaly

    Meet Dante—A Young Boy with Hemimegalencephaly

    Clips

    (2 min 33 sec) Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animations

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • Using DNA to Explore Lizard Phylogeny

    Using DNA to Explore Lizard Phylogeny

    Card Activities

    In this activity, students explore the phenomenon of convergent evolution presented in the short film The Origin of Species: Lizards in an Evolutionary Tree. They build and interpret phylogenetic trees to infer how certain adaptations evolved among the Anole lizard populations of the Caribbean.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Science Talks

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Science Talks

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Decoding the Autism Puzzle

    Decoding the Autism Puzzle

    Science Talks

    (58 min 5 sec) Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Science Talks

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Lessons

    In this activity, students evaluate and discuss statements about the evolutionary relationship between milk consumption and lactose tolerance discussed in the short film Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture.

  • The Origin of Species: Lizards in an Evolutionary Tree

    The Origin of Species: Lizards in an Evolutionary Tree

    Short Films

    (17 min 45 sec) This film explores the adaptation of anole lizards (genus Anolis) to habitats common across the islands of the Caribbean. The anoles are excellent examples of adaptive radiation, convergent evolution, and speciation through reproductive isolation.

  • Meet Chris Walsh

    Meet Chris Walsh

    Clips

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Science Talks

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Got Lactase? Blood Glucose Data Analysis

    Got Lactase? Blood Glucose Data Analysis

    Lessons

    Students interpret the results of two different tests for lactase persistence.

  • Using Genetic Crosses to Analyze a Stickleback Trait

    Using Genetic Crosses to Analyze a Stickleback Trait

    Card Activities

    A hands-on activity in which students analyze the results of genetic crosses between stickleback fish with different traits.

  • Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Labs & Demos

    A hands-on activity in which students interpret molecular diagrams and build physical models of eukaryotic gene regulation.

  • The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    Short Films

    (14 min 52 sec) This film explores the genetics and evolution of lactase persistence in humans.

  • Teacher Guide: AP Biology

    Teacher Guide: AP Biology

    Resource Guides

    This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 

  • The Making of the Fittest: Natural Selection in Humans

    The Making of the Fittest: Natural Selection in Humans

    Short Films

    (14 min 3 sec) This film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia.

  • The Making of the Fittest: The Birth and Death of Genes

    The Making of the Fittest: The Birth and Death of Genes

    Short Films

    (13 min 10 sec) Scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

  • Film Guides: The Birth and Death of Genes

    Film Guides: The Birth and Death of Genes

    Film Activities

    The following classroom-ready resources complement The Making of the Fittest: The Birth and Death of Genes, which describes how scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

  • Molecular Genetics of Color Mutations in Rock Pocket Mice

    Molecular Genetics of Color Mutations in Rock Pocket Mice

    Lessons

    In these activities, students transcribe and translate portions of the rock pocket mouse Mc1r gene to further explore the genetic variations responsible for different coat colors as described in the short film Making of the Fittest: Natural Selection and Adaptation.

  • Dengue Virus Life Cycle

    Dengue Virus Life Cycle

    Animations

    (4 min 12 sec) Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.

  • HIV life cycle

    HIV life cycle

    Animations

    (4 min 52 sec) How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.

  • Protease inhibitors

    Protease inhibitors

    Animations

    (1 min 6 sec) Protease inhibitors prevent maturation of viral proteins inside HIV particles.

  • AZT blocks reverse transcriptase

    AZT blocks reverse transcriptase

    Animations

    (1 min 46 sec) HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

  • Pitx1 Expression

    Pitx1 Expression

    Animations

    (55 sec) In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animations

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • Sickle Cell Anemia

    Sickle Cell Anemia

    Animations

    (1 min) Sickle cell anemia is a genetic disease that affects hemoglobin.

  • X Inactivation

    X Inactivation

    Animations

    (55 sec) This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes. 

  • Meiosis

    Meiosis

    Animations

    (5 min 53 sec) This animation shows how meiosis, the form of cell division unique to egg and sperm production, can give rise to sperm that carry either an X or a Y chromosome.  

  • Transgenic Fly Virtual Lab

    Transgenic Fly Virtual Lab

    Virtual Labs

    The lab will familiarize you with the science and techniques used to make transgenic flies to study circadian rhythms.

  • The Drosophila Molecular Clock Model

    The Drosophila Molecular Clock Model

    Animations

    (7 min 35 sec) Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

  • The Mammalian Molecular Clock Model

    The Mammalian Molecular Clock Model

    Animations

    (3 min 41 sec) This animation shows the molecular interactions involved in the negative feedback loop responsible for circadian rhythms in mammals.

  • Recombination of Viral Genome

    Recombination of Viral Genome

    Animations

    (3 min 5 sec) When two different strains of influenza infect a single cell, their genetic material can mix freely, resulting in a new third strain of influenza.

  • Cardiology Virtual Lab

    Cardiology Virtual Lab

    Virtual Labs

    NEW! HTML 5 support added! This virtual lab will familiarize you with heritable diseases of the heart. Learn about the diagnostic tools used to examine and diagnose patients.

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