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  • Living Together

    Living Together

    Phenomenal Images

    Students explore photos of bobtail squid as phenomena to explore symbiosis and species interactions.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Animated Life: Seeing the Invisible

    Animated Life: Seeing the Invisible

    Animated Shorts

    (6 min 31 sec) This animated feature celebrates 17th-century citizen-scientist Antonie van Leeuwenhoek, whose discoveries of microbes changed our view of the biological world. Also available in Spanish.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animations

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Science Talks

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Science Talks

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animations

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animations

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Cloning an Army of T Cells for Immune Defense

    Cloning an Army of T Cells for Immune Defense

    Animations

    (4 min 21 sec) View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Activities

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • Bacterial Quorum Sensing

    Bacterial Quorum Sensing

    Click & Learn

    Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.

  • Symbiotic Bioluminescence

    Symbiotic Bioluminescence

    Click & Learn

    Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.

  • Demonstration: Glowing bacteria in a flask

    Demonstration: Glowing bacteria in a flask

    Clips

    (52 sec) Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animations

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • Prialt blocks motor synapse in fish

    Prialt blocks motor synapse in fish

    Animations

    (2 min 31 sec) Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.

  • Electrical Activity of Neurons

    Electrical Activity of Neurons

    Click & Learn

    Measuring neuronal activity, generating action potentials, and recording the firing of individual neurons.

  • Demo: SHH concentration and eye position

    Demo: SHH concentration and eye position

    Clips

    (1 min 22 sec) A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

  • Demo: Electrical measurement of muscle activity

    Demo: Electrical measurement of muscle activity

    Clips

    (2 min 10 sec) A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.

  • Molecular Mechanism of Synaptic Function

    Molecular Mechanism of Synaptic Function

    Animations

    (1 min 9 sec) Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses. Also available in Spanish.

  • Signal molecules trigger transcription factors

    Signal molecules trigger transcription factors

    Animations

    (2 min 4 sec) Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

  • CTL killing a target cell

    CTL killing a target cell

    Clips

    (1 min 17 sec) Video microscopy of a cytotoxic T lymphocyte in action.

  • Antigen presentation and CTL

    Antigen presentation and CTL

    Animations

    (2 min 34 sec) How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads.

  • Creating Embryonic Stem Cell Lines

    Creating Embryonic Stem Cell Lines

    Animations

    (1 min 38 sec) The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

  • Zebrafish Heart Regeneration

    Zebrafish Heart Regeneration

    Animations

    (2 min 30 sec) The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.

  • What Is Fat?

    What Is Fat?

    Posters

    The poster from the 2004 Holiday Lectures on Science, The Science of Fat. See how fat is stored and metabolized. (This poster is designed to printed at a maximum size of 29.5" x 23.5".)

  • Leptin Feedback Control System

    Leptin Feedback Control System

    Animations

    (1 min 1 sec) Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animations

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • Angiogenesis

    Angiogenesis

    Animations

    (1 min 12 sec) A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs. Also available in Spanish.

  • VEGF

    VEGF

    Animations

    This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

  • The Drosophila Molecular Clock Model

    The Drosophila Molecular Clock Model

    Animations

    (7 min 35 sec) Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

  • Bacterial Conjugation

    Bacterial Conjugation

    Animations

    (23 sec) Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.

  • Neurophysiology Virtual Lab

    Neurophysiology Virtual Lab

    Virtual Labs

    In this virtual lab, you will record electrical activities of individual neurons, identify by response to stimuli, and use dyes to visualize their morphology.

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