Search Results

Search Results

Showing 1-58 of 58 Resources
  • Living Together

    Living Together

    Phenomenal Image

    Students explore photos of bobtail squid as an anchoring phenomenon to explore symbiosis and species interactions.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Animated Life: Seeing the Invisible

    Animated Life: Seeing the Invisible

    Animated Short

    (6 min 31 sec) This animated feature celebrates 17th-century citizen-scientist Antonie van Leeuwenhoek, whose discoveries of microbes changed our view of the biological world. Also available in Spanish.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animation

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Cloning an Army of T Cells for Immune Defense

    Cloning an Army of T Cells for Immune Defense

    Animation

    (4 min 21 sec) View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Activity

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • Bacterial Quorum Sensing

    Bacterial Quorum Sensing

    Click & Learn

    Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.

  • Symbiotic Bioluminescence

    Symbiotic Bioluminescence

    Click & Learn

    Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.

  • Q&A on Quorum Sensing

    Q&A on Quorum Sensing

    Lecture

    (12 min 59 sec) In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.

  • Eavesdropping on Tiny Conspiracies

    Eavesdropping on Tiny Conspiracies

    Lecture

    (58 min 29 sec) The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.

  • Biodiversity at a Snail's Pace

    Biodiversity at a Snail's Pace

    Lecture

    (58 min 29 sec) Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.

  • Shedding Light on an Invisible World

    Shedding Light on an Invisible World

    Lecture

    (58 min 29 sec) Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.

  • From Venoms to Drugs

    From Venoms to Drugs

    Lecture

    (58 min 29 sec) Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.

  • Exploring Biodiversity: The Search for New Medicines

    Exploring Biodiversity: The Search for New Medicines

    Lecture

    What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new medicines.

  • Demonstration: Quorum sensing molecules

    Demonstration: Quorum sensing molecules

    Clip

    (50 sec) Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.

  • Demonstration: Glowing bacteria in a flask

    Demonstration: Glowing bacteria in a flask

    Clip

    (52 sec) Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animation

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • Prialt blocks motor synapse in fish

    Prialt blocks motor synapse in fish

    Animation

    (2 min 31 sec) Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.

  • Prialt blocks pain signaling in mice

    Prialt blocks pain signaling in mice

    Animation

    (2 min 58 sec) Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.

  • The molecular cascade in bacterial quorum sensing

    The molecular cascade in bacterial quorum sensing

    Animation

    (3 min 20 sec) Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.

  • Electrical Activity of Neurons

    Electrical Activity of Neurons

    Click & Learn

    Measuring neuronal activity, generating action potentials, and recording the firing of individual neurons.

  • Memories are Made of This

    Memories are Made of This

    Lecture

    (58 min 29 sec) The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice. Molecular basis of Alzheimer's disease.

  • Plan of Action: How the Spinal Cord Controls Movement

    Plan of Action: How the Spinal Cord Controls Movement

    Lecture

    (58 min 29 sec) Understanding the neural circuits in the spinal cord that control movement.

  • Building Brains: The Molecular Logic of Neural Circuits

    Building Brains: The Molecular Logic of Neural Circuits

    Lecture

    (58 min 29 sec) How a nerve cell gets its identity, sends axons, and makes connections with other cells.

  • Visualizing learning

    Visualizing learning

    Clip

    (5 min 39 sec) Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.

  • Demo: SHH concentration and eye position

    Demo: SHH concentration and eye position

    Clip

    (1 min 22 sec) A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

  • Long-distance neuronal path-finding

    Long-distance neuronal path-finding

    Clip

    (31 sec) Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.

  • Contact repulsion of a growth cone

    Contact repulsion of a growth cone

    Clip

    (1 min 5 sec) A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.

  • Demo: Electrical measurement of muscle activity

    Demo: Electrical measurement of muscle activity

    Clip

    (2 min 10 sec) A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.

  • Molecular basis of late LTP (long-term memory)

    Molecular basis of late LTP (long-term memory)

    Animation

    (57 sec) Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.

  • Molecular basis of early LTP (short-term memory)

    Molecular basis of early LTP (short-term memory)

    Animation

    (1 min 27 sec) Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.

  • Molecular activity in Aplysia short-term memory

    Molecular activity in Aplysia short-term memory

    Animation

    (2 min 30 sec) Short-term memory relies on serotonin activating a protein kinase to modify existing synaptic strength.

  • Molecular activity in Aplysia long-term memory

    Molecular activity in Aplysia long-term memory

    Animation

    (1 min 39 sec) Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.

  • Molecular Mechanism of Synaptic Function

    Molecular Mechanism of Synaptic Function

    Animation

    (1 min 9 sec) Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses. Also available in Spanish.

  • Repellant ephrin signals guide limb innervations

    Repellant ephrin signals guide limb innervations

    Animation

    (1 min 34 sec) The growth cone of a neuron avoids repellant molecules and navigates to innervate the appropriate muscle.

  • Signal molecules trigger transcription factors

    Signal molecules trigger transcription factors

    Animation

    (2 min 4 sec) Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

  • AIDS: Evolution of an Epidemic

    AIDS: Evolution of an Epidemic

    Lecture

    Why has it been so hard to develop a vaccine against HIV? How are new medicines revolutionizing AIDS treatment? Can AIDS be cured?

  • CTL killing a target cell

    CTL killing a target cell

    Clip

    (1 min 17 sec) Video microscopy of a cytotoxic T lymphocyte in action.

  • Antigen presentation and CTL

    Antigen presentation and CTL

    Animation

    (2 min 34 sec) How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads.

  • Creating Embryonic Stem Cell Lines

    Creating Embryonic Stem Cell Lines

    Animation

    (1 min 38 sec) The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

  • Zebrafish Heart Regeneration

    Zebrafish Heart Regeneration

    Animation

    (2 min 30 sec) The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.

  • What Is Fat?

    What Is Fat?

    Poster

    The poster from the 2004 Holiday Lectures on Science, The Science of Fat. See how fat is stored and metabolized. (This poster is designed to printed at a maximum size of 29.5" x 23.5".)

  • The Science of Fat

    The Science of Fat

    Lecture

    In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health. Awards 2006 Telly Awards; Silver

  • Leptin Feedback Control System

    Leptin Feedback Control System

    Animation

    (1 min 1 sec) Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animation

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • Angiogenesis

    Angiogenesis

    Animation

    (1 min 12 sec) A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs. Also available in Spanish.

  • VEGF

    VEGF

    Animation

    This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

  • The Meaning of Sex: Genes and Gender

    The Meaning of Sex: Genes and Gender

    Lecture

    Four talks focus on sex determination—the molecular and genetic mechanisms that determine whether an organism will be male, female or a hermaphrodite.

  • Clockwork Genes: Discoveries in Biological Time

    Clockwork Genes: Discoveries in Biological Time

    Lecture

    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

  • The Drosophila Molecular Clock Model

    The Drosophila Molecular Clock Model

    Animation

    (7 min 35 sec) Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

  • 2000 and Beyond: Confronting the Microbe Menace

    2000 and Beyond: Confronting the Microbe Menace

    Lecture

    (57 min 36 sec) In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics arise.

  • Bacterial Conjugation

    Bacterial Conjugation

    Animation

    (23 sec) Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.

  • Neurophysiology Virtual Lab

    Neurophysiology Virtual Lab

    Virtual Lab

    In this virtual lab, you will record electrical activities of individual neurons, identify by response to stimuli, and use dyes to visualize their morphology.

  • Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Lecture

    In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.

Refine Results

Narrow your choices by selecting areas below.

Topics

Extended Filters