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Showing 1-22 of 22 Resources
  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    Explore this dynamic interactive to learn the basic principles of how this revolutionary tool works and the many ways in which scientists are using it in their research.

  • Solving Crimes with the NECROBIOME

    Solving Crimes with the NECROBIOME

    Feature Films

    (7 min 10 sec) We can’t talk to the dead, but in their own way, the dead can speak to us.

  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) How do you identify the disease-causing mutation in a patient with an inherited disease? This video illustrates the steps involved—testing for genes that are the “usual suspects,” searching for mutations in novel genes, and assessing links between genotype and phenotype.

  • Think Like a Scientist: Natural Selection in an Outbreak

    Think Like a Scientist: Natural Selection in an Outbreak

    Scientists at Work

    (7 min 29 sec) This video brings us to the front lines of the 2013–2015 Ebola outbreak in west Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Points

    A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

  • Holiday Lecture 2004 Update—Jeff Friedman

    Holiday Lecture 2004 Update—Jeff Friedman

    Clips

    (3 min 52 sec) HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Activities

    In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clips

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clips

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Dog Genomics and Dogs as Model Organisms

    Dog Genomics and Dogs as Model Organisms

    Science Talks

    (28 min 54 sec) Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Science Talks

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Science Talks

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Decoding the Autism Puzzle

    Decoding the Autism Puzzle

    Science Talks

    (58 min 5 sec) Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Science Talks

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Meet Charles Sawyers

    Meet Charles Sawyers

    Clips

    (2 min 27 sec) Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer. 

  • Meet Chris Walsh

    Meet Chris Walsh

    Clips

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Science Talks

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Leading-Edge Bioinformatics

    Leading-Edge Bioinformatics

    Clips

    (6 min 36 sec) Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.

  • Shotgun sequencing

    Shotgun sequencing

    Animations

    (1 min) In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.

  • Human genome sequencing

    Human genome sequencing

    Animations

    (1 min 49 sec) The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA in question, many fragments represented the same part of the genome. These were aligned by identifying overlapping regions of the sequence, and then they were assembled into the original DNA.

  • Using DNA to Trace Human Migration

    Using DNA to Trace Human Migration

    Click & Learn

    All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.

  • How to Analyze DNA Microarray Data

    How to Analyze DNA Microarray Data

    Click & Learn

    DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.

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