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Showing 1-61 of 61 Resources
  • Sodium Channel Evolution in Electric Fish

    Sodium Channel Evolution in Electric Fish

    Data Points

    Scientists investigated how gene duplication contributed to the evolution of electric fish.

  • Sex Verification Testing of Athletes

    Sex Verification Testing of Athletes

    Click & Learn

    This interactive module explores the biology of sex determination and development in humans, set against the backdrop of the different sex testing policies implemented throughout sports history.

  • Developing an Explanation for Mouse Fur Color

    Developing an Explanation for Mouse Fur Color

    Lessons

    In this activity, students collect and analyze evidence for each of the major conditions for evolution by natural selection to develop an explanation for how populations change over time.

  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animations

    (2 min 31 sec) This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.

  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research.

  • Pelvic Evolution in Sticklebacks

    Pelvic Evolution in Sticklebacks

    Data Points

    This activity guides the analysis of a published scientific figure from a study that used SNP genotyping to identify the mutations that result in morphological differences in stickleback fish.

  • “Fixing” Gene Expression

    “Fixing” Gene Expression

    Card Activities

    In this hands-on activity, students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat different genetic conditions. The activity reinforces concepts covered in the Click & Learn “Central Dogma and Genetic Medicine.”

  • Monkey Social Status and Immune Response

    Monkey Social Status and Immune Response

    Data Points

    This activity guides the analysis of a published scientific figure from a study on how social status affects the expression of genes involved in immune system processes.

  • Activity for Genes as Medicine

    Activity for Genes as Medicine

    Film Activities

    This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.

  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) This video describes the case of a patient with retinitis pigmentosa (RP), a progressive disease that leads to blindness, and how physician-scientist Dr. Ed Stone approached the search for the causal mutation.

  • Genes as Medicine

    Genes as Medicine

    Short Films

    (17 min 16 sec) This film describes the scientific principles and the research efforts involved in the development of a gene therapy for a congenital form of blindness, and how a young patient benefited from this medical breakthrough.

  • Stalking the Genetic Basis of a Trait

    Stalking the Genetic Basis of a Trait

    Lessons

    This activity supports the film Popped Secret: The Mysterious Origin of Corn. Students analyze data on the expression of the tb1 gene to explain how variations in this gene played a role in the evolution of corn.

  • Central Dogma and Genetic Medicine

    Central Dogma and Genetic Medicine

    Click & Learn

    This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions.

  • Patterns in the Distribution of Lactase Persistence

    Patterns in the Distribution of Lactase Persistence

    Card Activities

    This activity extends concepts covered in the film Got Lactase? The Co-Evolution of Genes and Culture. Students analyze data from the scientific literature to draw conclusions about the geographic distribution of lactase persistence.

  • Think Like a Scientist: Natural Selection in an Outbreak

    Think Like a Scientist: Natural Selection in an Outbreak

    Scientists at Work

    (7 min 29 sec) This video focuses on the front lines of the 2013–2016 Ebola outbreak in West Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

  • DNA Profiling Activity

    DNA Profiling Activity

    Case Studies

    This multipart activity is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world.

  • Genetically Modified Mosquitoes

    Genetically Modified Mosquitoes

    Scientists at Work

    (8 min 35 sec) This video describes the process by which a line of genetically modified mosquitoes was engineered to reduce populations of wild mosquitoes.

  • Understanding Variation in Human Skin Color

    Understanding Variation in Human Skin Color

    Lessons

    In this activity, students extend the concepts covered in the short film The Biology of Skin Color through the application of models and mathematical thinking to explain how genomic variation and human ancestry can explain differences in skin color, a polygenic trait.

  • Alzheimer’s Disease: Piecing Together the Evidence

    Alzheimer’s Disease: Piecing Together the Evidence

    Click & Learn

    This interactive module allows students to examine evidence from brain anatomy, tissue histology, and genetic studies to identify possible targets for the treatment of Alzheimer’s disease.

  • Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Data Points

    This activity guides the analysis of a published scientific figure from a study involving illegal elephant poaching. In this study, scientists used DNA profiling to determine where ivory seized from poachers had originated.

  • CSI Wildlife

    CSI Wildlife

    Click & Learn

    This interactive module allows students to use DNA profiling and related biological concepts to solve two cases of elephant poaching.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Points

    This activity analyzes a published scientific figure from a study of a family that has a high prevalence of Alzheimer’s disease.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Points

    This activity guides the analysis of a published scientific figure from a study that used SNP genotyping to identify genes involved in autism.

  • The Teosinte Hypothesis

    The Teosinte Hypothesis

    Lessons

    In this activity, students further explore the short film Popped Secret: The Mysterious Origin of Corn, by working through the mathematical concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize.

  • Genetic Origin of Variation in Human Skin Color

    Genetic Origin of Variation in Human Skin Color

    Data Points

    This activity guides the analysis of a published scientific figure from a study that investigated a gene involved in determining human skin color.

  • Activity for Popped Secret: The Mysterious Origin of Corn

    Activity for Popped Secret: The Mysterious Origin of Corn

    Film Activities

    This activity explores how scientists determined how and where corn was domesticated, as discussed in the short film Popped Secret: The Mysterious Origin of Corn.

  • Activity for The Biology of Skin Color

    Activity for The Biology of Skin Color

    Film Activities

    This activity explores the evidence that differences in human skin color are adaptations to varying intensity of UV light, as discussed in the short film The Biology of Skin Color.

  • How We Get Our Skin Color

    How We Get Our Skin Color

    Animations

    (3 min 32 sec) This animation describes how skin color is generated by skin cells as protection against ultraviolet (UV) radiation.

  • The Biology of Skin Color

    The Biology of Skin Color

    Short Films

    (18 min 58 sec) This film explores the hypothesis that different tones of skin color in humans arose as adaptations to the intensity of ultraviolet radiation in different parts of the world.

  • Popped Secret: The Mysterious Origin of Corn

    Popped Secret: The Mysterious Origin of Corn

    Short Films

    (17 min 51 sec) This film explores the genetic and archaeological evidence that suggest that corn is the result of the domestication of a wild Mexican grass called teosinte.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animations

    (1 min 40 sec) This animation shows how transcription factors find their binding sites in real time. It is based on data from an imaging method that can track single molecules in a living cell.

  • Pedigrees and the Inheritance of Lactose Intolerance

    Pedigrees and the Inheritance of Lactose Intolerance

    Lessons

    In this activity, students explore concepts covered in the short film Got Lactase? The Co-evolution of Genes and Culture about the genetic variations associated with lactose tolerance/intolerance and how the trait is inherited in families.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Card Activities

    In this activity, students identify single nucleotide polymorphisms (SNPs) that are correlated with different traits in dogs to identify genes associated with those traits.

  • Classifying Cancer Genes and Examining Patient Data

    Classifying Cancer Genes and Examining Patient Data

    Card Activities

    These two hands-on activities engage students in exploring the genetic basis of cancer using cards and posters.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animations

    (2 min 3 sec) This animation shows how genes associated with autism affect the structure and function of neuronal synapses.

  • Resistance to a Medication for Chronic Myeloid Leukemia

    Resistance to a Medication for Chronic Myeloid Leukemia

    Animations

    (2 min 14 sec) This animation shows why a mutant BCR-ABL protein is resistant to the cancer treatment drug Gleevec, and how a new drug can overcome this resistance.

  • Mechanism of a Medication for Chronic Myeloid Leukemia

    Mechanism of a Medication for Chronic Myeloid Leukemia

    Animations

    (3 min 31 sec) This animation shows how the cancer treatment Gleevec inhibits the cancer-causing protein BCR-ABL.

  • The Origin of Species: Lizards in an Evolutionary Tree

    The Origin of Species: Lizards in an Evolutionary Tree

    Short Films

    (17 min 45 sec) This film explores the adaptation of anole lizards (genus Anolis) to habitats common across the islands of the Caribbean. The anoles are excellent examples of adaptive radiation, convergent evolution, and speciation through reproductive isolation.

  • Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Labs & Demos

    This hands-on activity supports concepts covered in the film Evolving Switches, Evolving Bodies about the evolution of stickleback fish. Students interpret molecular diagrams and build physical models of eukaryotic gene regulation.

  • Natural Selection for Lactose Tolerance

    Natural Selection for Lactose Tolerance

    Animations

    (46 sec) This animation shows how a mutation that allows adult humans to digest milk can be lost or spread under different circumstances.

  • Regulation of Eukaryotic DNA Transcription

    Regulation of Eukaryotic DNA Transcription

    Animations

    (2 min 5 sec) This animation shows how a variety of proteins interact to regulate the transcription of eukaryotic DNA into RNA.

  • Dengue Virus Life Cycle

    Dengue Virus Life Cycle

    Animations

    (4 min 12 sec) This animation shows how dengue virus infects a cell and replicates itself with the help of its host’s cellular machinery.

  • The Chemical Structure of DNA

    The Chemical Structure of DNA

    Animations

    (2 min 44 sec) This animation explores the chemical components and bonds of the nucleotides that make up DNA.

  • Polymerase Chain Reaction (PCR)

    Polymerase Chain Reaction (PCR)

    Animations

    (1 min 28 sec) This animation describes PCR, a standard laboratory technique for making many copies of a specific DNA sequence.

  • The LUX Operon

    The LUX Operon

    Animations

    (2 min 25 sec) This animation explores the LUX operon, a set of five genes that are involved in bacterial bioluminescence.

  • HIV Life Cycle

    HIV Life Cycle

    Animations

    (4 min 52 sec) This animation shows how HIV infects a cell and replicates itself using reverse transcriptase.

  • Treating HIV Infection with Protease Inhibitors

    Treating HIV Infection with Protease Inhibitors

    Animations

    (1 min 6 sec) This animation shows how medications called protease inhibitors can be used to treat HIV/AIDS.

  • Treating HIV Infection with a Reverse Transcriptase Inhibitor

    Treating HIV Infection with a Reverse Transcriptase Inhibitor

    Animations

    (1 min 46 sec) This animation shows how a medication called AZT, which is a reverse transcriptase inhibitor, can be used to treat HIV/AIDS.

  • Visualizing Gene-Expression Patterns

    Visualizing Gene-Expression Patterns

    Click & Learn

    This tutorial describes methods used to detect when and where genes are expressed in cells and tissues.

  • The p53 Gene and Cancer

    The p53 Gene and Cancer

    Click & Learn

    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

  • Triplet Code

    Triplet Code

    Animations

    (1 min 8 sec) This animation describes how many nucleotides encode a single amino acid, which is a key part of the genetic code.

  • Translation (advanced detail)

    Translation (advanced detail)

    Animations

    (3 min 4 sec) Messenger RNA (mRNA) carries DNA's genetic information to the ribosome, where it is translated into a sequence of amino acids. mRNA is fed into the ribosome, and it is positioned so that it can be read in groups of three letters, known as codons. Each mRNA codon is matched against the transfer RNA molecule's anti-codon. If there is a match, the amino acid carried by the transfer RNA is added to the growing protein chain. Also available in Spanish.

  • Translation (Basic Detail)

    Translation (Basic Detail)

    Animations

    (2 min 6 sec) This animation shows the translation of messenger RNA into protein.

  • DNA Transcription (Advanced Detail)

    DNA Transcription (Advanced Detail)

    Animations

    (1 min 55 sec) This animation shows how RNA polymerase and other transcription factors interact to transcribe DNA into RNA.

  • DNA Transcription (Basic Detail)

    DNA Transcription (Basic Detail)

    Animations

    (1 min 55 sec) This animation shows the transcription of DNA into RNA.

  • Sickle Cell Disease

    Sickle Cell Disease

    Animations

    (1 min) This animation explores the genetic causes and biological effects of sickle cell disease.

  • RNA Splicing

    RNA Splicing

    Animations

    (39 sec) This animation shows how mRNA is edited to remove noncoding regions.

  • X Inactivation

    X Inactivation

    Animations

    (55 sec) This animation shows how X chromosomes are randomly switched off in most female mammals.

  • RNA Diversity

    RNA Diversity

    Click & Learn

    This tutorial explores the many types of RNA molecules that exist and their functions.

  • Enzymes That Are Not Proteins: The Discovery of Ribozymes

    Enzymes That Are Not Proteins: The Discovery of Ribozymes

    Clips

    (19 min 4 sec) Listen to past HHMI President Dr. Thomas Cech discussing his Nobel Prize-winning discovery of RNA's catalytic properties.

  • RNA Folding

    RNA Folding

    Animations

    (33 sec) This animation shows how RNA molecules can form different structures, including ones that look and act like proteins.

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