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  • Pulse Chase Primer: The Meselson-Stahl Experiment

    Pulse Chase Primer: The Meselson-Stahl Experiment

    Activities

    This activity can be used in conjunction with the short film The Double Helix. It introduces students to the classic experiment by Matthew Meselson and Franklin Stahl, which revealed that DNA replication follows the semiconservative model.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clips

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • CLARITY—Cutting Edge Microscopy for Brain Imaging

    CLARITY—Cutting Edge Microscopy for Brain Imaging

    Clips

    (1 min 17 sec) A new technique for making the brain transparent provides extremely detailed views of groups of neurons.

  • The Making of a Theory—Fact or Fiction

    The Making of a Theory—Fact or Fiction

    Activities

    This activity supports the viewing of the film The Origin of Species: The Making of a Theory. Before and after watching the film, students discuss and evaluate several statements about Charles Darwin, Alfred Russel Wallace, and the specific evidence that led each of them to the theory of evolution by natural selection.

  • EarthViewer Climate Guide Activity

    EarthViewer Climate Guide Activity

    Activities

    This student worksheet highlights climate concepts in the EarthViewer app.

  • Earth Systems Activity

    Earth Systems Activity

    Activities

    This activity guides students through building a conceptual model of how carbon dioxide affects Earth's climate

  • Beaks As Tools: Selective Advantage in Changing Environments

    Beaks As Tools: Selective Advantage in Changing Environments

    Activities

    This classroom experiment supports the film The Origin of Species: The Beak of the Finch. Students collect and analyze data to learn why even slight variations in beak size can make the difference between life and death.

  • Using DNA to Explore Lizard Phylogeny

    Using DNA to Explore Lizard Phylogeny

    Activities

    This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are guided to sort the lizard species by appearance, then generate a phylogenetic tree using the lizards’ DNA sequences to evaluate whether species that appear similar are closely related to each other.

  • Great Transitions: The Origin of Tetrapods

    Great Transitions: The Origin of Tetrapods

    Short Films

    (17 min 11 sec) One of the most exciting discoveries in the long history of fossil exploration is Tiktaalik, a creature with a mix of features common to fish and four-legged animals, or tetrapods.

  • Evolution in Action: Data Analysis

    Evolution in Action: Data Analysis

    Activities

    These two activities support the film The Origin of Species: The Beak of the Finch. They provide students with the opportunity to analyze data collected by Princeton University evolutionary biologists Peter and Rosemary Grant.

  • Film Guides: The Origin of Species: The Making of a Theory

    Film Guides: The Origin of Species: The Making of a Theory

    Film Guides

    The following classroom-ready resources complement The Origin of Species: The Making of a Theory, which tells the story of the epic adventures of Charles Darwin and Alfred Russel Wallace and of the evidence they gathered for the theory of evolution by means of natural selection

  • The Animated Life of A. R. Wallace

    The Animated Life of A. R. Wallace

    Animated Shorts

    (7 min 45 sec) This animated short video illustrates the life of Alfred Russel Wallace, who independently formulated the theory of evolution by natural selection at the same time as Charles Darwin.

  • Film Guides: The Double Helix

    Film Guides: The Double Helix

    Film Guides

    The following classroom-ready resources complement The Double Helix. This short film describes the evidence that led James Watson and Francis Crick to the discovery of the double-helical structure of DNA and how the structure immediately revealed how genetic information is stored and inherited.

  • The Double Helix

    The Double Helix

    Short Films

    (16 min 53 sec) The Double Helix is the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Also available in Spanish.

  • The Origin of Species: The Making of a Theory

    The Origin of Species: The Making of a Theory

    Short Films

    (30 min 51 sec) The epic voyages of Darwin and Wallace led each to independently discover the natural origin of species and to formulate the theory of evolution by natural selection. Also available in Spanish.

  • Got Lactase? Blood Glucose Data Analysis

    Got Lactase? Blood Glucose Data Analysis

    Activities

    Students interpret the results of two different tests for lactase persistence.

  • Finding the Crater

    Finding the Crater

    Activities

    This hands-on activity requires students to “visit” different K-T boundary sites.

  • Teacher Guide: Biotechnology

    Teacher Guide: Biotechnology

    Resource Guides

    Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarray. This guide includes multiple classroom-ready worksheets to accompany HHMI’s virtual labs.

  • Teacher Guide: AP Biology

    Teacher Guide: AP Biology

    Resource Guides

    This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 

  • Classroom Activities: What is My Carbon Footprint?

    Classroom Activities: What is My Carbon Footprint?

    Activities

    To accompany the lecture series Changing Planet: Past, Present, Future. Using an online calculator, you will estimate your household’s carbon footprint and explore various actions to reduce it. Also available in Spanish.

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