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  • Developing an Explanation for Mouse Fur Color

    Developing an Explanation for Mouse Fur Color

    Lessons

    In this activity, students collect and analyze evidence for each of the major conditions for evolution by natural selection to develop an explanation for how populations change over time.

  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animations

    (2 min 31 sec) This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.

  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research.

  • Pelvic Evolution in Sticklebacks

    Pelvic Evolution in Sticklebacks

    Data Points

    This activity guides the analysis of a published scientific figure from a study that used SNP genotyping to identify the mutations that result in morphological differences in stickleback fish.

  • “Fixing” Gene Expression

    “Fixing” Gene Expression

    Card Activities

    In this hands-on activity, students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat different genetic conditions. The activity reinforces concepts covered in the Click & Learn “Central Dogma and Genetic Medicine.”

  • Activity for Genes as Medicine

    Activity for Genes as Medicine

    Film Activities

    This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.

  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) This video describes the case of a patient with retinitis pigmentosa (RP), a progressive disease that leads to blindness, and how physician-scientist Dr. Ed Stone approached the search for the causal mutation.

  • Genes as Medicine

    Genes as Medicine

    Short Films

    (17 min 16 sec) This film describes the scientific principles and the research efforts involved in the development of a gene therapy for a congenital form of blindness, and how a young patient benefited from this medical breakthrough.

  • Central Dogma and Genetic Medicine

    Central Dogma and Genetic Medicine

    Click & Learn

    This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions.

  • DNA Profiling Activity

    DNA Profiling Activity

    Case Studies

    This multipart activity is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world.

  • Genetically Modified Mosquitoes

    Genetically Modified Mosquitoes

    Scientists at Work

    (8 min 35 sec) This video describes the process by which a line of genetically modified mosquitoes was engineered to reduce populations of wild mosquitoes.

  • Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Data Points

    This activity guides the analysis of a published scientific figure from a study involving illegal elephant poaching. In this study, scientists used DNA profiling to determine where ivory seized from poachers had originated.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Points

    This activity analyzes a published scientific figure from a study of a family that has a high prevalence of Alzheimer’s disease.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Points

    This activity guides the analysis of a published scientific figure from a study that used SNP genotyping to identify genes involved in autism.

  • The Teosinte Hypothesis

    The Teosinte Hypothesis

    Lessons

    In this activity, students further explore the short film Popped Secret: The Mysterious Origin of Corn, by working through the mathematical concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize.

  • Genetic Origin of Variation in Human Skin Color

    Genetic Origin of Variation in Human Skin Color

    Data Points

    This activity guides the analysis of a published scientific figure from a study that investigated a gene involved in determining human skin color.

  • Activity for Popped Secret: The Mysterious Origin of Corn

    Activity for Popped Secret: The Mysterious Origin of Corn

    Film Activities

    This activity explores how scientists determined how and where corn was domesticated, as discussed in the short film Popped Secret: The Mysterious Origin of Corn.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Card Activities

    In this activity, students identify single nucleotide polymorphisms (SNPs) that are correlated with different traits in dogs to identify genes associated with those traits.

  • Pulse Chase Primer: The Meselson-Stahl Experiment

    Pulse Chase Primer: The Meselson-Stahl Experiment

    Lessons

    This activity can be used in conjunction with the short film The Double Helix. It introduces students to the classic experiment by Matthew Meselson and Franklin Stahl, which revealed that DNA replication follows the semiconservative model.

  • Activity for The Double Helix

    Activity for The Double Helix

    Film Activities

    This activity explores the concepts and research presented in the short film The Double Helix, which tells the story of the discovery of the molecular structure of DNA.

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