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  • Developing an Explanation for Mouse Fur Color

    Developing an Explanation for Mouse Fur Color

    Activities

    Students collect and analyze evidence for each of the major conditions for evolution by natural selection to develop an explanation for how populations change over time. Also available in Spanish.

  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animations

    (2 min 31 sec) Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    Explore this dynamic interactive to learn the basic principles of how this revolutionary tool works and the many ways in which scientists are using it in their research.

  • Pelvic Evolution in Sticklebacks

    Pelvic Evolution in Sticklebacks

    Data Points

    Scientists used SNP genotyping in populations of freshwater stickleback fish to determine the genetic mutations responsible for the impaired development of pelvises and spines.

  • Central Dogma Card Activity

    Central Dogma Card Activity

    Activities

    In this hands-on activity students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat genetic disease.

  • Film Guide for Genes as Medicine

    Film Guide for Genes as Medicine

    Film Guides

    The following classroom-ready resources complement the film Genes as Medicine. It tells the story of the successes and challenges that led to the development of the first FDA-approved gene therapy for a genetic disease.

  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) How do you identify the disease-causing mutation in a patient with an inherited disease? This video illustrates the steps involved—testing for genes that are the “usual suspects,” searching for mutations in novel genes, and assessing links between genotype and phenotype.

  • Genes as Medicine

    Genes as Medicine

    Short Films

    (17 min 16 sec) Watch the story of how gene therapy restored the sight of a nearly-blind young patient. Told from the perspective of two researchers who spent over 25 years working to develop this breakthrough technology, this short film chronicles their successes and challenges, and illustrates how the method works to treat inherited conditions.

  • Central Dogma and Genetic Medicine

    Central Dogma and Genetic Medicine

    Click & Learn

    This interactive uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat genetic diseases.

  • Resource Guides

    Resource Guides

    Collection

    Designed by educators, BioInteractive’s resource guides will help you select BioInteractive resources aligned to specific topics and standards, including the AP® Biology Curriculum Framework.

  • DNA Profiling Activity

    DNA Profiling Activity

    Activities

    This multi-part lesson is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world. 

  • Genetically Modified Mosquitoes

    Genetically Modified Mosquitoes

    Scientists at Work

    (8 min 35 sec) Learn the process by which a line of genetically modified mosquitoes was engineered to reduce populations of Aedes aegypti mosquitoes in the wild.

  • Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Data Points

    A team of scientists analyzed the DNA from seized ivory to determine where the ivory from poached elephants came from.

  • CSI Wildlife

    CSI Wildlife

    Click & Learn

    In this interactive, students use DNA profiling, or fingerprinting, to solve two cases of elephant poaching. In the process they will learn about genetic markers, PCR, gel electrophoresis, allele frequencies, and population genetics.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Points

    A team of scientists built a pedigree of a large extended family in Antioquia, Colombia, that has a high prevalence of early-onset familial Alzheimer’s disease due to a mutation in the PSEN1 gene. Worksheets also available in Spanish.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Points

    A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

  • The Teosinte Hypothesis

    The Teosinte Hypothesis

    Activities

    In this lesson, students work through the mathematics and concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize. Also available in Spanish.

  • Genetic Origin of Variation in Human Skin Color

    Genetic Origin of Variation in Human Skin Color

    Data Points

    Dr. Rebecca Lamason and colleagues studied the genetic origin of variation in human skin color using a model organism, the zebrafish.

  • How Species Coexist

    How Species Coexist

    Science Talks

    (27 min 25 sec) Large herbivores in the African savanna coexist by partitioning ecological niches by time, space, and diet.

  • Film Guide for Popped Secret: The Mysterious Origin of Corn

    Film Guide for Popped Secret: The Mysterious Origin of Corn

    Film Guides

    The following classroom-ready resources complement the film Popped Secret: The Mysterious Origin of Corn, which tells the story of how geneticists and archaeologists have come together to determine how and where corn was domesticated nearly 9,000 years ago. Also available in Spanish.

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