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Showing 1-20 of 29 Resources
  • Role of p53 in the Cell Cycle

    Role of p53 in the Cell Cycle

    Data Point

    Researchers investigated the role of p53 in cell cycle regulation by genetically engineering a cell line with deleted copies of the p53 gene. They exposed the cell lines to DNA-damaging radiation and observed how this exposure impacted mitosis.

  • Cell Division and Cancer Risk

    Cell Division and Cancer Risk

    Data Point

    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Point

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Video

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Dasatinib

    Dasatinib

    3D Model

    A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.


  • Imatinib (Gleevec)

    Imatinib (Gleevec)

    3D Model

    A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.

  • Adenosine Triphosphate (ATP)

    Adenosine Triphosphate (ATP)

    3D Model

    A 3D model of adenosine triphosphate, or ATP.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • Cancer and Cell Fate in the Intestinal Epithelium

    Cancer and Cell Fate in the Intestinal Epithelium

    Animation

    (2 min 17 sec) Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer. Also available in Spanish.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

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