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  • Identifying the Key Genes for Regeneration

    Identifying the Key Genes for Regeneration

    Scientists at Work

    (9 min 55 sec) Planarians have an amazing ability to regenerate lost tissues. In this video, scientists knock out two different genes in planaria to start to understand how the process works—and they generate animals with two heads and two tails!

  • Root Movement

    Root Movement

    Phenomenal Images

    Students explore photos of plant cells as an anchoring phenomenon to explore the response of plant cells to stimuli.

  • Classroom Activities: Planaria Regeneration Activity

    Classroom Activities: Planaria Regeneration Activity

    Activities

    This activity uses the planaria's property for regeneration and compares how long it takes for planaria cut in different places to regenerate a head. 

  • Classroom Activities: Stem Cells and Diabetes

    Classroom Activities: Stem Cells and Diabetes

    Activities

    To accompany the lecture series Potent Biology: Stem Cells, Cloning, and Regeneration.

  • Stem-Cell-Based Therapies

    Stem-Cell-Based Therapies

    Click & Learn

    An exploration of current and future therapies.

  • Tissue Regeneration in Animals

    Tissue Regeneration in Animals

    Click & Learn

    An overview and comparison of different regenerative capabilities in many different organisms.

  • Somatic Cell Nuclear Transfer Video

    Somatic Cell Nuclear Transfer Video

    Clips

    (2 min) Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another.

  • Planarian Regeneration and Stem Cells

    Planarian Regeneration and Stem Cells

    Scientists at Work

    (11 min 47 sec) A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

  • Human Embryonic Development

    Human Embryonic Development

    Animations

    (2 min 18 sec) Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during gastrulation, the three germ layers form, and most cells become more restricted in the types of cells that they can produce.

  • Differentiation and the Fate of Cells

    Differentiation and the Fate of Cells

    Animations

    (1 min 29 sec) As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become even more restricted. For example, the pancreatic bud of the endoderm layer can only make the cells of the pancreas.

  • Creating Embryonic Stem Cell Lines

    Creating Embryonic Stem Cell Lines

    Animations

    (1 min 38 sec) The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

  • Newt Limb Regeneration

    Newt Limb Regeneration

    Animations

    (1 min 21 sec) Urodele amphibians—newts and salamanders—are able to regenerate fully functional limbs in response to amputation. Cells in and near the limb stump dedifferentiate to form a mass of stemlike cells that can produce all the specialized tissues of the limb, such as muscle, nerves, and blood vessels.

  • Somatic Cell Nuclear Transfer Animation

    Somatic Cell Nuclear Transfer Animation

    Animations

    (52 sec) Somatic cell nuclear transfer (SCNT) is a technique for cloning. The nucleus is removed from a healthy egg. This egg becomes the host for a nucleus that is transplanted from another cell, such as a skin cell. The resulting embryo can be used to generate embryonic stem cells with a genetic match to the nucleus donor (therapeutic cloning), or can be implanted into a surrogate mother to create a cloned individual, such as Dolly the sheep (reproductive cloning).

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