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  • Why Two Heads?

    Why Two Heads?

    Phenomenal Images

    Students explore images of planarians regenerating body parts as an anchoring phenomenon to explore cell division and differentiation.

  • Sex Verification Testing of Athletes

    Sex Verification Testing of Athletes

    Click & Learn

    This interactive explores the biology of sex determination and development in humans, set against the backdrop of the different sex testing policies implemented throughout sports history.

  • Identifying the Key Genes for Regeneration

    Identifying the Key Genes for Regeneration

    Scientists at Work

    (9 min 55 sec) Planarians have an amazing ability to regenerate lost tissues. In this video, scientists knock out two different genes in planaria to start to understand how the process works—and they generate animals with two heads and two tails!

  • Genetic Mutations and Disease Interactive

    Genetic Mutations and Disease Interactive

    Click & Learn

    This interactive focuses on the roles of germline and somatic cell mutations in human disease. It supports the 2013 Holiday Lectures on Science, Medicine in the Genomic Era.

  • Dante's Story

    Dante's Story

    Clips

    (6 min 6 sec) Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clips

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Meet Dante—A Young Boy with Hemimegalencephaly

    Meet Dante—A Young Boy with Hemimegalencephaly

    Clips

    (2 min 33 sec) Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

  • Development of the Cerebral Cortex

    Development of the Cerebral Cortex

    Animations

    (1 min 43 sec) Most of the neurons of the cerebral cortex arise from progenitor cells that undergo repeated cell division.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Science Talks

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Meet Chris Walsh

    Meet Chris Walsh

    Clips

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

  • Genetic Mutations and Disease

    Genetic Mutations and Disease

    Posters

    The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

  • Demo: SHH concentration and eye position

    Demo: SHH concentration and eye position

    Clips

    (1 min 22 sec) A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

  • Growth cones in action

    Growth cones in action

    Clips

    (34 sec) The growth cones of two neurons sense and interact with one another.

  • Development of the human embryonic brain

    Development of the human embryonic brain

    Animations

    (1 min 40 sec) The fetal brain grows enormously during pregnancy, both in terms of its size and the number of neurons it has.

  • Signal molecules trigger transcription factors

    Signal molecules trigger transcription factors

    Animations

    (2 min 4 sec) Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

  • Classroom Activities: Stem Cells and Diabetes

    Classroom Activities: Stem Cells and Diabetes

    Activities

    To accompany the lecture series Potent Biology: Stem Cells, Cloning, and Regeneration.

  • Planarian Regeneration and Stem Cells

    Planarian Regeneration and Stem Cells

    Scientists at Work

    (11 min 47 sec) A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

  • Human Embryonic Development

    Human Embryonic Development

    Animations

    (2 min 18 sec) Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during gastrulation, the three germ layers form, and most cells become more restricted in the types of cells that they can produce.

  • Differentiation and the Fate of Cells

    Differentiation and the Fate of Cells

    Animations

    (1 min 29 sec) As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become even more restricted. For example, the pancreatic bud of the endoderm layer can only make the cells of the pancreas.

  • Creating Embryonic Stem Cell Lines

    Creating Embryonic Stem Cell Lines

    Animations

    (1 min 38 sec) The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

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