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Showing 1-20 of 41 Resources
  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animation

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Cloning an Army of T Cells for Immune Defense

    Cloning an Army of T Cells for Immune Defense

    Animation

    (4 min 21 sec) View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

  • Symbiotic Bioluminescence

    Symbiotic Bioluminescence

    Click & Learn

    Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.

  • Biodiversity at a Snail's Pace

    Biodiversity at a Snail's Pace

    Lecture

    (58 min 29 sec) Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.

  • From Venoms to Drugs

    From Venoms to Drugs

    Lecture

    (58 min 29 sec) Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.

  • Exploring Biodiversity: The Search for New Medicines

    Exploring Biodiversity: The Search for New Medicines

    Lecture

    What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new medicines.

  • Prialt blocks motor synapse in fish

    Prialt blocks motor synapse in fish

    Animation

    (2 min 31 sec) Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.

  • Prialt blocks pain signaling in mice

    Prialt blocks pain signaling in mice

    Animation

    (2 min 58 sec) Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.

  • Electrical Activity of Neurons

    Electrical Activity of Neurons

    Click & Learn

    Measuring neuronal activity, generating action potentials, and recording the firing of individual neurons.

  • Memories are Made of This

    Memories are Made of This

    Lecture

    (58 min 29 sec) The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice. Molecular basis of Alzheimer's disease.

  • Plan of Action: How the Spinal Cord Controls Movement

    Plan of Action: How the Spinal Cord Controls Movement

    Lecture

    (58 min 29 sec) Understanding the neural circuits in the spinal cord that control movement.

  • Building Brains: The Molecular Logic of Neural Circuits

    Building Brains: The Molecular Logic of Neural Circuits

    Lecture

    (58 min 29 sec) How a nerve cell gets its identity, sends axons, and makes connections with other cells.

  • Visualizing learning

    Visualizing learning

    Clip

    (5 min 39 sec) Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.

  • Demo: SHH concentration and eye position

    Demo: SHH concentration and eye position

    Clip

    (1 min 22 sec) A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

  • Long-distance neuronal path-finding

    Long-distance neuronal path-finding

    Clip

    (31 sec) Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.

  • Contact repulsion of a growth cone

    Contact repulsion of a growth cone

    Clip

    (1 min 5 sec) A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.

  • Demo: Electrical measurement of muscle activity

    Demo: Electrical measurement of muscle activity

    Clip

    (2 min 10 sec) A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.

  • Molecular basis of late LTP (long-term memory)

    Molecular basis of late LTP (long-term memory)

    Animation

    (57 sec) Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.

  • Molecular basis of early LTP (short-term memory)

    Molecular basis of early LTP (short-term memory)

    Animation

    (1 min 27 sec) Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.

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