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Showing 21-38 of 38 Resources
  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Lecture

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Medicine in the Genomic Era

    Medicine in the Genomic Era

    Lecture

    In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

  • Teacher Guide: Gene Regulation

    Teacher Guide: Gene Regulation

    Teacher Guide

    Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.

  • Testing a Hypothesis

    Testing a Hypothesis

    Activity

    A worksheet designed to actively engage students as they watch the film. Students are asked to answer questions pertaining to the information provided in the film.

  • The Making of the Fittest: Natural Selection in Humans

    The Making of the Fittest: Natural Selection in Humans

    Short Film

    (14 min 3 sec) In some parts of the world, there is an intimate connection between the infectious parasitic disease malaria and the genetic disease sickle cell anemia. Also available in Spanish

  • How Do Fibers Form?

    How Do Fibers Form?

    Activity

    A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.

  • Film Guides: Natural Selection in Humans

    Film Guides: Natural Selection in Humans

    Film Guide

    The following classroom-ready resources complement The Making of the Fittest: Natural Selection in Humans, which describes the connection between malaria and sickle cell anemia—one of the best-understood examples of natural selection in humans. Also available in Spanish.

  • The Molecular Evolution of Gene Birth and Death

    The Molecular Evolution of Gene Birth and Death

    Activity

    An advanced lesson that describes the role of mutations in the birth and death of genes. It includes background information, examples, video clips, and animations.

  • Classroom Activities: Pedigree Analysis Activity

    Classroom Activities: Pedigree Analysis Activity

    Activity

    To accompany the lecture series Learning from Patients: The Science of Medicine.

  • Learning from Patients: The Science of Medicine

    Learning from Patients: The Science of Medicine

    Lecture

    As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

  • SCA1 Mouse on Rotarod

    SCA1 Mouse on Rotarod

    Clip

    (35 sec) Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

  • Sickle Cell Anemia

    Sickle Cell Anemia

    Animation

    (1 min) Sickle cell anemia is a genetic disease that affects hemoglobin.

  • Tri Nucleotide Repeat

    Tri Nucleotide Repeat

    Animation

    (1 min 8 sec) Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs. 

  • Cardiology Virtual Lab

    Cardiology Virtual Lab

    Virtual Lab

    NEW! HTML 5 support added! This virtual lab will familiarize you with heritable diseases of the heart. Learn about the diagnostic tools used to examine and diagnose patients.

  • Of Hearts and Hypertension: Blazing Genetic Trails

    Of Hearts and Hypertension: Blazing Genetic Trails

    Lecture

    In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.

  • Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Senses and Sensitivity: Neuronal Alliances for Sight and Sound

    Lecture

    In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.

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