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Showing 1-18 of 18 Resources
  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animation

    (2 min 31 sec) Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    Explore this dynamic interactive to learn the basic principles of how this revolutionary tool works and the many ways in which scientists are using it in their research.

  • Monkey Social Status and Immune Response

    Monkey Social Status and Immune Response

    Data Point

    Scientists studied how the dominance ranking of female rhesus macaques living in social groups affected the expression of genes linked to immune response

  • Film Guide for Genes as Medicine

    Film Guide for Genes as Medicine

    Film Guide

    The following classroom-ready resources complement the film Genes as Medicine. It tells the story of the successes and challenges that led to the development of the first FDA-approved gene therapy for a genetic disease.

  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) How do you identify the disease-causing mutation in a patient with an inherited disease? This video illustrates the steps involved—testing for genes that are the “usual suspects,” searching for mutations in novel genes, and assessing links between genotype and phenotype.

  • Genes as Medicine

    Genes as Medicine

    Short Film

    (17 min 16 sec) Watch the story of how gene therapy restored the sight of a nearly-blind young patient. Told from the perspective of two researchers who spent over 25 years working to develop this breakthrough technology, this short film chronicles their successes and challenges, and illustrates how the method works to treat inherited conditions.

  • Central Dogma and Genetic Medicine

    Central Dogma and Genetic Medicine

    Click & Learn

    This interactive uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat genetic diseases.

  • Alzheimer’s Disease: Piecing Together the Evidence

    Alzheimer’s Disease: Piecing Together the Evidence

    Click & Learn

    This interactive explores evidence from brain anatomy, tissue histology, and genetic studies to reveal possible targets for the treatment of Alzheimer’s disease.

  • Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

    Data Point

    A team of scientists built a pedigree of a large extended family in Antioquia, Colombia, that has a high prevalence of early-onset familial Alzheimer’s disease due to a mutation in the PSEN1 gene. Worksheets also available in Spanish.

  • Identifying Autism Genes by Tracking Gene Mutations

    Identifying Autism Genes by Tracking Gene Mutations

    Data Point

    A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animation

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • Testing a Hypothesis

    Testing a Hypothesis

    Activity

    A worksheet designed to actively engage students as they watch the film. Students are asked to answer questions pertaining to the information provided in the film.

  • How Do Fibers Form?

    How Do Fibers Form?

    Activity

    A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.

  • Film Guides: Natural Selection in Humans

    Film Guides: Natural Selection in Humans

    Film Guide

    The following classroom-ready resources complement The Making of the Fittest: Natural Selection in Humans, which describes the connection between malaria and sickle cell anemia—one of the best-understood examples of natural selection in humans. Also available in Spanish.

  • The Molecular Evolution of Gene Birth and Death

    The Molecular Evolution of Gene Birth and Death

    Activity

    An advanced lesson that describes the role of mutations in the birth and death of genes. It includes background information, examples, video clips, and animations.

  • Sickle Cell Anemia

    Sickle Cell Anemia

    Animation

    (1 min) Sickle cell anemia is a genetic disease that affects hemoglobin.

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